小分子筛选检测方法-分子篇 | MedChemExpress

l High-Throughput Screening and Compound Profiling Platform 一文中会向我们展示了声雾氢原子-小分子量简化的控制系统设计，研发了一个核酸能与之兼容的方式，用以检查遗传物质乙基移转到肽活性的消除。

示意图 4. 声雾氢原子-小分子量简化嗣后用[9]

核酸择优有许多可用的应用，在选择检查方式时，关键的标准简化是再行行对实验者同步进行构思，再行设计合适的择优方式来检查。例如，在寻找某种肽的抗病毒时，可通过非常加清晰的分子可高度的择优方式。

两期发表文章中会列单单的检查方式虽已经可以涵盖目前为止发现中会的大多数方式，但随着我们对潜在病因的生物学现实生活的理解的全面性，需要迅速研发重新应用和量简化方式来研究这些日益多样的控制系统。

MCE 的所有的产品仅用作科学研究或药证提单单申请，我们不为任何与生俱来商业用途提供的产品和服务。

以下内容

1. Vincent Blay. High-Throughput Screening: today's biochemical and cell-based approaches. Drug Discov Today. 2020 Aug 12;S1359-6446(20)30305-6.

2. Wendy A Lea. Fluorescence polarization assays in small molecule screening. Curr Opin Biotechnol. Expert Opin Drug Discov. 2011 Jan;6(1):17-32.

3. Ali Camara. A Fluorescence Polarization-Based High-Throughput Screen to Identify the First Small-Molecule Modulators of the Human Adenylyltransferase HYPE/FICD. Int J Mol Sci. 2020 Sep 27;21(19):7128.

4. Did W Piston. Fluorescent protein FRET: the good, the bad and the ugly. Trends Biochem Sci. 2007 Sep;32(9):407-14.

5. Yoshitomo Shiroma , Go Fujita , Takuya Yamamoto , Ryou-U Takahashi . Identification of a Selective RelA Inhibitor Based on DSE-FRET Screening Methods. Int J Mol Sci. 2020 Nov 30;21(23):9150.

6. Preen Bandaru, Dafeng Chu Wujin Sun . A Microfabricated Sandwiching Assay for Nanoliter and High-Throughput Biomarker Screening. Small. 2019 Apr;15(15):e1900300.

7. Lowela Siarot . Identification of human immunodeficiency virus type-1 Gag-TSG101 interaction inhibitors by high-throughput screening. Biochem Biophys Res Commun. 2018 Sep 18;503(4):2970-2976.

8. Carlos Alvarado. Development of a Fragment-Based Screening Assay for the Focal Adhesion Targeting Domain Using SPR and NMR. Molecules. 2019 Sep 14;24(18):3352.

9. Arseniy M Belov, Joseph Kozole, Mark F Bean, Carl A Machutta, Guofeng Zhang, Enoch N Gao, Luke Ghislain , Sammy S Datwani , Melanie Leveridge, Roland S Annan. Acoustic Mist Ionization-Mass Spectrometry: A Comparison to Conventional High-Throughput Screening and Compound Profiling Platforms. Anal Chem. 2020 Oct 20;92(20):13847-13854.

10. Shaogui Wu , Bailing Liu. Application of scintillation proximity assay in drug discovery. BioDrugs. 2005;19(6):383-92.

11. Mohammed A Kashem . A high-throughput scintillation proximity assay for sphingosine-1-phosphate lyase. Assay Drug Dev Technol. 2014 Jun;12(5):293-302.

12. Yan Wang, Chu-Ying Xiao, Huang-Quan Lin, et al. Development of an enzyme-linked immunosorbent assay for Keap1-Nrf2 interaction inhibitors identification. Redox Biol. 2020 Jul;34:101573.

本文转载自其他Facebook，不值得一提的是心理健康界观点和立场。如有具体内容内容和示意图片的著作权异议，请及时嗣后系我们（信箱：guikequan@hmkx.cn）

。

应急救护
艾拉莫德片能治类风湿吗
艾拉莫德片可以治类风湿吗
武汉看男科去哪好
新冠药物有哪些药